Esketamine Therapy

When Depression Hasn’t Responded to Traditional Treatment, There Is Still Hope

At Mindville, we understand how discouraging it can feel to live with depression that doesn’t improve despite trying multiple medications or therapy approaches. If you’ve been doing everything asked of you and still don’t feel like yourself, you are not alone — and you are not out of options.

We offer esketamine therapy as part of our integrative mental health approach for individuals with treatment-resistant depression.

What Is Esketamine?

Esketamine is an FDA-approved medication for adults with treatment-resistant depression. It works differently from traditional antidepressants and targets neural pathways involved in mood, cognition, and emotional processing.

Unlike medications that can take weeks to show effect, esketamine may provide more rapid relief for some individuals — particularly those who have not responded adequately to standard treatments.

Esketamine is administered as a nasal spray in a monitored clinical setting, in combination with an oral antidepressant.

Who May Benefit from Esketamine Therapy

Esketamine may be appropriate if you:

Have depression that has not improved after trying multiple antidepressants
Feel emotionally numb, stuck, or hopeless despite ongoing care
Experience significant impairment in daily functioning
Are seeking evidence-based options beyond traditional medication adjustments
Want care that is thoughtful, structured, and closely monitored

A comprehensive evaluation is required to determine whether esketamine is an appropriate and safe option for you.

Our Integrative, Supportive Approach

At Mindville, esketamine is not offered as a standalone solution. We believe meaningful healing happens when innovative treatments are combined with individualized, compassionate care.

Your treatment plan may include:

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Thorough psychiatric evaluation

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Thoughtful medication management

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Ongoing monitoring and support

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Integration of lifestyle and mental health strategies

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Collaboration around your personal goals and values

Throughout treatment, you are supported in a calm, respectful environment where safety, dignity, and connection matter.

What to Expect During Treatment

Esketamine is administered in-office under medical supervision

Each session includes a monitoring period for safety and comfort

Treatment occurs on a structured schedule, especially during the initial phase

We closely track symptoms, response, and overall well-being

Our team remains actively involved before, during, and after each session to ensure you feel informed, supported, and cared for.

A Path Forward

For many individuals, treatment-resistant depression can create a sense of hopelessness or self-blame. At Mindville, we approach this differently.

Needing advanced treatment does not mean you have failed — it means your brain may need a different kind of support.

Esketamine therapy offers a science-backed option that, when thoughtfully integrated into care, may help restore hope, clarity, and momentum.

Is Esketamine Right for You?

Esketamine therapy may be a good fit if you:

Have not found adequate relief with traditional treatments
Want an integrative, closely monitored approach
Value personalized care over one-size-fits-all solutions
Are ready to explore innovative options with professional guidance

If you’re ready to learn whether esketamine could be part of your healing journey, Mindville is here to help.

Frequently Asked Questions

Insurance coverage for esketamine varies by plan. Many commercial insurance plans and some government plans provide coverage for FDA-approved esketamine treatment when medical criteria are met. Our office assists with benefits verification and prior authorization whenever possible and will review coverage details with you before treatment begins.

If insurance coverage is limited or unavailable, we can discuss self-pay options and expected costs transparently.

Esketamine is FDA-approved and has been studied extensively for treatment-resistant depression. At Mindville, safety is a priority.

Treatment is provided in-office under medical supervision
Vital signs and clinical response are monitored during each session
Patients remain on-site for observation following administration

Most side effects are temporary and may include dissociation, dizziness, nausea, or changes in blood pressure. These effects typically resolve within hours. A comprehensive evaluation is completed to ensure esketamine is an appropriate and safe option for you.

Costs depend on insurance coverage, copays, deductibles, and whether self-pay is required. We believe in transparency and will review anticipated costs with you before starting treatment so there are no surprises.

Our team is happy to answer financial questions and help you understand your options.

Esketamine treatment follows a structured schedule:

Initial phase typically involves two sessions per week for several weeks
Each visit lasts approximately 2–3 hours, including monitoring time
Maintenance frequency is individualized based on response

Because esketamine can temporarily affect alertness, patients must arrange transportation home after each session and should not drive or return to work the same day.

Request a Consultation

To schedule an evaluation or learn more about esketamine therapy at Mindville, please contact our office or request an appointment through our website.

Book an Appointment